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Data plotted log 2 of the fold change versus DMSO control against log 10 of the P -value per protein (3 independent experiments)

In the STEP-1 trial of 1,961 adults (Wilding and colleagues, Once-Weekly Semaglutide in Adults with Overweight or Obesity, New England Journal of Medicine, 2021), participants on semaglutide 2.4 mg lost an average of 14.9 percent of their body weight at 68 weeks, compared to 2.4 percent on placebo

The intensity of this signal is directly proportional to the concentration of antibody present in the original specimen

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One way this is done is through conjugation with GST (glutathione S-transferase) enzymes