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Voluntary wheel running in rodents is supported by both motivational and automatic processes, and can display features reminiscent of compulsivity or automaticity (Eikelboom and Mills, 1988

Administering the lowest effective microdose and waiting extended periods between dose increases is the standard protocol for reducing gastrointestinal distress in animal models and human trials

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Most long-term exercise interventions have proven to decrease FM while improving physical performance, along with significant improvement in cardiorespiratory fitness and increased muscle strength [55, 56]

doi: 10.1001/jama2021.1831 15 RubinoDAbrahamssonNDaviesMHesseDGreenwayFLJensenCet al

Ouimet M, Barrett TJ, Fisher EA