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reported that Exos derived from adipose-derived stem cells (ADSC-Exos) deliver Fxr2, which stabilizes Atf3 mRNA in M2 microglia, therapy inhibiting ferroptosis, reducing inflammation and promoting neuronal survival [138]
Their applications span ADCs, protein-drug conjugates (PDCs), peptide conjugates, and small molecule conjugates, providing powerful tools for modern drug development and biotechnology
PubMed, Zhang, Xian, et al
The reasons cited by the FDA included concerns about immunogenicity, peptide impurity characterization challenges, and the lack of adequate safety data from human clinical trials
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