GLP-1 is also produced by pancreatic islet cells and neurons within the NTS of the brainstem.56 The peptide is rapidly degraded by dipeptidyl peptidase-4 into GLP-1 amide and subsequently cleared renally, resulting in a short half-life of approximately two minutes.47 Activation of the G protein-coupled GLP-1 receptor increases intracellular calcium concentrations within pancreatic islets, thereby promoting insulin exocytosis
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Treatment of SM, positive control for hyperlipidemia, significantly improved lipid condition compared to control rats
Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations
John Wiley & Sons, New York Molina JA, Jimenez-Jimenez FJ, Gomez P, Vargas C, Navarro JA, Orti-Pareja M, Gasalla T, Benito-Leon J, Bermejo F, Arenas J (1997) Decreased cerebrospinal fluid levels of neutral and basic amino acids in patients with Parkinsons disease
Among the key players in iron homeostasis, solute carrier family 40 member 1 (SLC40A1, also known as ferroportin) is the only known iron exporter in mammals, pivotal for orchestrating cellular iron dynamics in ferroptotic pancreatic cancer cells [104]
