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In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group.5 These results establish CagriSema as one of the most potent antiobesity therapies investigated to date

however, many people still don't fully understand precisely why inflammation lies at the root of most health concerns plaguing Americans today

Other clinical data showed microbiota shifts (fewer beneficial, more harmful bacteria) with constipation and delayed gastric emptying, underscoring the diagnostic significance of microbiota composition changes [34]

Cardiovascular diabetology

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Second, the inclusion of both patients with type 2 diabetes mellitus (T2D) and non-diabetic individuals introduces clinical complexity