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At the molecular level, kaempferitrin exerts its anti-depressant potential by modulating the activity of the serotonergic system, particularly through presynaptic 5-HT1A receptors and regulating hypothalamic-hypophysis-adrenal axis (HPA) ( 5.4 Icariin Icariin, also known as a prenylated flavonol glycoside, is an 8-prenyl derivative of kaempferol 3,7-O-glucoside

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