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This is consistent with tolerance of K1A substitution in human Amy (hAmy) for cAMP potency at AMYRs 18

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N Engl J Med 381(9):841851 Bethel MA, Mentz RJ, Merrill P, Buse JB, Chan JC, Goodman SG et al (2018) Renal outcomes in the EXenatide study of cardiovascular event lowering (EXSCEL)