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experimental studies with other GLP-1 analogues (exendin-4 and liraglutide) have shown evidence of inhibition of oxidative stress, decreased apoptosis and prevalence of injured cells, decreased vascular proliferation, and increased c AMP levels in neurons and anti-inflammatory activity in microglial cells [67]

But heres the catch: studies show that over 80% of individuals regain at least 25% of the weight within a year after stopping treatment if lifestyle changes arent in place

Beneficial effects of GLP-1 agonist in a male with compulsive food-related behavior associated with autism

The absolute risk for these complications however is extremely uncommon, less than 1 per cent per year of use (Eckert)

Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

To put this into raw numbers, 84 cases of ischemic optic neuropathy were reported in people taking semaglutide over the 7 years