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In individuals with primary coenzyme Q 10 deficiency, early treatment with high-dose coenzyme Q 10 supplementation (1030 mg/kg/day in children and 1.23.0 g/day in adults) may improve the pathological phenotype, yet the effectiveness depends on the type of mutations affecting the coenzyme Q 10 biosynthetic pathway (1, 26)

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By specifying these elementseligibility criteria, treatment strategies, assignment procedures, follow-up period, and outcomesour retrospective analysis mimics the structure of a pragmatic RCT where the randomization is replaced by comprehensive propensity score matching

References 1 AguilarE