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Matthews DR, Li Q, Perkovic V, et al

Cellular Repair and Regeneration : Antioxidants enable cells to repair oxidative damage and maintain efficient function

By supplying folate that is already fully methylated, the supplement entirely bypasses the MTHFR enzymatic bottleneck

J Am Acad Dermatol, 32(2/1): 212-217

When low-and-slow dosing (or staying at the starting dose) makes sense and why not everyone needs aggressive escalation

Other indications include malabsorption disorders (such as Crohn's disease or coeliac disease), following gastric surgery, strict vegan diets without supplementation, and certain medications that interfere with B12 absorption