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It is resetting

The NHS and NICE recommend lifestyle modifications including regular physical activity and dietary changes as first-line approaches to managing weight during menopause, with pharmacological interventions such as GLP-1 receptor agonists considered only in specific circumstances

Additional information Peer review information Nature Communications thanks the anonymous reviewer(s) for their contribution to the peer review of this work

Inflammatory markers, while they do tend to rise with weight regain, may not return to their pre-treatment peaks if the regain is partial rather than complete

This dual-action approach is what makes it so effective

Common Side Effects & Risks GLP-1 RAs can come with some unwanted side effects