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Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

however, Wegovy contains a much higher dose of semaglutide

Do not attempt a 4mg dose at this concentration because 1.60mL exceeds what a standard 1mL insulin syringe can hold, and the injection volume itself becomes uncomfortable

Rapid weight loss can also affect body composition and hormone levels, including estrogen, which plays an important role in maintaining vaginal health and supporting protective lactobacillus bacteria, says registered dietician Lenia Lopez

GLP-1s have been used to treat Type 2 Diabetes since 2005