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Tolerance may be reversed by administration of hydrocortisone (Sun & Hanig, 1983

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The TRANSCEND-T2D-1 trial showed a 2.0% HbA1c reduction and 16.8% weight loss in 537 patients with type 2 diabetes over 40 weeks

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Energy dips are most pronounced in the first 13 weeks of treatment or during dose escalations

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