USA 118 , e2021357118 (2021)
Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores
The best results come from combining treatment with lifestyle changes and regular doctor visits
Conclusion In the DSIP nasal spray vs injection debate, there is no strict winner. Both delivery forms of DSIP aim to support better sleep quality, deeper restorative sleep, and improved regulation of sleep-wake cycles and the circadian rhythm but they differ in how you use them and what trade-offs you accept
Otro documento que habla del uso de L-Carnitina en el tratamiento de peso es el documento de I.Lofgren, T.Zern, .Herrn, K
10.1002/ptr.7754 130 SharmaV.ManhasA.GuptaS.DikshitM.JagaveluK.VermaR