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Acknowledgements This research was supported by the South Carolina Clinical & Translational Research Institute, with an academic home at the Medical University of South Carolina, CTSA NIH/NCATS grant numbers UL1TR001450 and UL1TR000062, NIH F31NS108623, and NIDA DA003906

In vivo evaluation demonstrated that mice tolerated LAAM GSH-CQDs at doses up to 5000 mg kg 1 , compared to 18 mg kg 1 for LAAM TC-CQDs, 12 mg kg 1 for Lipo 2000, and 16 mg kg 1 for GO-CQDs

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