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In the majority of the trials, the primary composite CV endpoint was a three-component major adverse CV event (MACE) outcome including CV-related mortality, non-fatal myocardial infarction (MI), and non-fatal stroke (the CVOT investigating lixisenatide, the ELIXA trial, also included time to the first occurrence of hospitalisation for unstable angina pectoris)

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This temporal difference means the two agents may complement each other if patient monitoring is rigorous and dosing is conservative

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The half-life of GLP-1 in the plasma circulation is only 12 minutes, due to the action of dipeptidyl peptidase (DDP-4) which inactivates GLP-1