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Current studies suggest that peripherally administered GLP-1RA has low concentrations in the cerebrospinal fluid, and higher doses or improved delivery systems (e.g., nanoparticles, liposome encapsulation) may be needed to increase brain exposure
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This alleviates the limitation on the pyruvate dehydrogenase complex (PDH), enhancing the transformation of glucose into energy and facilitating ATP production (98)
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[147] [148] Zelman started investigating after observing a fatty liver in a hospital employee who drank more than twenty bottles of Coca-Cola a day