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As the key metabolic enzymes, SHMTs are the direct transcriptional targets of c-Myc (Nikiforov et al., 2002
It is made in the liver, and it is one of the bodys main ways of handling toxins, inflammation, and damaged cells
In this review we will focus on (a) GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis (ischemic heart disease and stroke), (b) importance of oxidative stress and antioxidants in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 disease, (c) significance of GSH to counteract persistent damaging inflammation, inflammaging and early (premature) inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and (d) new therapies that include antioxidant defenses restoration
A prior check list should be to have realistic approach and expectation
Glutathione helps protect cells from free radical damage by acting as an antioxidant
