Stage 3: Brain Fog, Anxiety, & Cognitive Disruption You may think brain fog doesnt sound like a medical condition, but it is
Raven et al184 underscored the importance of considering the interactions between GLP-1RAs therapy, comorbid conditions, and concomitant medications that may also delay gastric emptying
In addition, similar to other GLP-1 RAs, it affects different stages of the pathophysiological process of CVDs, from risk factors like dyslipidemia, hypertension, obesity, diabetes, and coronary artery atherosclerosis to more advanced stages such as myocardial ischemia, atherothrombosis, myocardial infarction, left ventricular remodeling, and death, without raising the risk of arrhythmia, hospitalization, or exacerbating heart failure [35, 41]
A more comprehensive description of baseline characteristics is provided in Table S3 : Baseline characteristics in the supplementary material
Other positive CV outcome trials for SGLT-2 inhibitors followed, 8,9 and in a meta-analysis the class clearly shows a significant 10% reduction of major CV events related to atherosclerotic CV disease, which has informed the changes to the PBS
Market Limiters Production and Supply Constraints The increasing demand for GLP-1 receptor agonists, particularly due to their expanding indications beyond diabetes (e.g., obesity and kidney disease), puts significant pressure on manufacturing capacities
