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Degradation enhancement is caused mainly by the activation of the UPS (such as the increased expression of key factors MuRF1 and atrogin-1) and the autophagy-lysosome system (ALS), which together accelerate muscle protein degradation under oxidative stress [38]

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Hydralazine is used for severe hypertension to prevent eclampsia or intracranial hemorrhage, and minoxidil is used for resistant hypertension (10)(3)