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Studies in this population are limited, but emerging observations suggest rapid weight loss from semaglutide in slim people can include significant muscle mass depletion alongside fat loss, since the body draws from available protein stores when overall calories decline sharply

In line with these results, Wardle et al

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FIGURE 8 3.8 Immunohistochemical findings The immunohistochemical investigation demonstrated a significant increase in expression of proapoptotic makers, Bax, and caspase-3, in MTX treated group, which was associated with decreased antiapoptotic marker, Bcl-2, expression when compared to the CTRL group (Figure 9)

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