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Mounjaro/Zepbound (tirzepatide), approved dual GLP-1/GIP agonist for type 2 diabetes and obesity Recent Highlights: In April 2026, the FDA approved orforglipron (Foundayo), making it one of the first oral GLP-1 pills that can be taken any time of day and that has no food or water restrictions

Rapid weakness, severe fatigue, confusion, or inability to eat enough

Constipation Checklist for GLP-1 Patients Fatigue on GLP-1 Therapy: Medication Side Effect or Under-Fueling

Side effects often appear during the early weeks of treatment or after dose increases

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Because they're classed as food supplements, they don't go through the same safety checks as prescription medications