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Similar improvements in functional and histological healing have been reported across independent rat ligament- and muscle-injury models, synthesized in a 2025 systematic review

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2.4 Gene Expression Modulation: Genomic studies (e.g., Pickart et al., 2012) reveal GHK-Cu resets over 4,000 genes to a youthful state, upregulating repair genes and downregulating inflammatory ones, a unique epigenetic effect

Ionized calcium-binding adapter molecule 1 immunoreactive cells change in the gerbil hippocampal CA1 region after ischemia/reperfusion