Plus, free radicals in the body cause damage to internal organs
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Long-term metformin use may reduce vitamin B12 absorption, and NICE recommends considering B12 monitoring in patients with symptoms of deficiency (such as anaemia or neuropathy) or risk factors for malabsorption
Strategies to improve bioavailability, half-life in vivo, rapid renal clearance of GH-RH antagonists, and in vivo stability were developed 48,65,69,70,71,72
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