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Caffeine metabolism varies greatly between individuals, owing primarily to differences in CYP1A2 enzyme activity, and there has recently been renewed interest in identifying polymorphisms that influence caffeine metabolism
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Justin Carlson (right) presented a lecture, " Beyond the Guidelines: Sacubitril/Valsartan (ARNi) (Entresto) ", in which he reported on 49 case studies of MVD-affected dogs in late Stage C or Stage D ("pretty bad cases that I thought were not going to do very well"), 7 of which were cavalier King Charles spaniels (and 7 Maltese and 6 Yorkies)
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