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The practical translation is: choose steady, not extreme

A secondary analysis of a randomized clinical trial examined changes in BMD at clinically significant sites following an 8-week low-calorie diet (800 kcal/day) for weight loss, followed by a year-long treatment with liraglutide (3.0 mg daily), exercise alone (a supervised and progressive resistance training program), a combination of both treatments (liraglutide + exercise), or a placebo [74]

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PubMed Nauck, M.A., Quast, D.R., Wefers, J., & Meier, J.J

Whether you are using GLP-1 medications or considering them, it is essential to be aware of the possible side effects and complications that go along with taking any medication