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These metabolic transformations play a crucial role in the pharmacokinetics and bioavailability of curcumin, impacting its therapeutic potential and effectiveness ( FIGURE 2 2.1.1.2 Bioavailability of curcumin Two aromatic ring systems in curcumin include o-methoxy phenolic groups connected by a seven-carbon connector made up of an , -unsaturated -diketone moiety (Karthikeyan et al., 2020)

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placebo in patients who were overweight or obese and showed sustained, clinically relevant weight loss and improvement in lipid parameters