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The study of pernicious anemia patients with relapse of anemia (Figure 10) (53) has shown that the depletion of serum vitamin B-12 after folic acid administration is accompanied by a proportional increase in reticulocyte counts, suggesting that serum vitamin B-12 is diverted into the hematopoietic system to provide the necessary vitamin B-12 coenzyme for methionine production

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128 In a double-blind, randomized, controlled trial in 85 women with PCOS who received either 1,000 mcg chromium picolinate or placebo daily for six months, chromium picolinate supplementation led to significant improvements in BMI and fasting serum insulin levels

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Throughout the treatment, close medical supervision is critical