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doi:10.1136/flgastro-2020-101566 [61] Adamczak A, Oarowski M, Karpiski TM

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It is the mechanism by which the therapy works at all

Lancet 373 , 17651772 (2009)

This new paradigm began with the discovery of leptin, by Jeff Friedman and others in 1994, the first hormone whose primary function is the regulation of body weight, by signaling from the adipose tissue to pro-opiomelanocortin (POMC) neurons [6] in the hypothalamus to reduce food intake