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It is already facing hundreds of lawsuits filed by patients who experienced severe side effects after taking Zepbound for weight loss

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In a substudy from the obesity trial, retatrutide was studied for liver fat change at 24 weeks in a defined participant subgroup, using imaging based endpoints

Mechanism of Action Incretins hormones like GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) are released throughout the day, increasing at mealtimes

These companies currently offer five GLP-1 drugs approved for type 2 diabetes, with four also approved for various cardiovascular conditions

The primary mechanism of action involves binding to GLP-1 receptors on pancreatic beta cells, which stimulates glucose-dependent insulin secretion and suppresses inappropriate glucagon release