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The most studied member of this class of enzymes is sirtuin 1 (SIRT1), whose expression is associated with increasing insulin sensitivity

Recent meta-analyses grade it low certainty with no consistent overall increase (Liu 2025)

Quick tip: To avoid surprise costs, its a good idea to check with your provider or plan administrator early

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According to the UK product information, these include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea and constipation (very common) Vomiting and abdominal pain (common) Reduced appetite and indigestion (common) Flatulence and bloating (common) These symptoms are generally mild to moderate and tend to improve as the body adjusts to the medication