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Hepatol Res 38:11221129

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Adverse effects of incretin mimetics Potential adverse effects of incretin mimetics include: Hypoglycemia when taken with insulin GI distress Pancreatitis Renal insufficiency Possible risk of thyroid cancer Other non-insulin, injectable diabetes medications GIP/GLP-1 receptor co-agonists GIP/GLP-1 receptor co-agonists are used to treat type 2 diabetes only

Evidence for this comes from the Otsuka Long Evans Tokushima Fatty rat which has a null mutation in the CCK-1 receptor

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While overlap exists between RP and LPS-induced pneumonitis in signaling pathways, their principal inflammatory cascades are not entirely identical (Table 2)