Increased activity of PRPP synthetase, in this circumstance, has the same consequences as defects in the PRPS gene that lead to superactivity of PRPP synthetase described above
Abstract Patients receiving hemodialysis also manifest gastrointestinal symptoms, such as constipation, caused by restriction of water intake and the loss of body water balance
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Role of AP1 binding site contained within human antioxidant response element
Safety and Tolerability Both compounds share a dominant, mostly mild-to-moderate gastrointestinal adverse-event profile nausea, vomiting, diarrhea, constipation, abdominal pain concentrated during dose escalation
Key limitation: With only 3 patients per group, even a single unusually responsive or non-responsive patient could substantially skew the results