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The failure to directly detect GSS by us and others 31,32 is in line with their stability toward other molecules (including spin traps) on the one hand and their rapid disappearance (through self-recombination) on the other

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GSSG forms when two GSH molecules are linked by a disulfide bond between their cysteine residues

Wu GD, Compher C, Chen EZ, Smith SA, Shah RD, Bittinger K, et al

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From the literature we do have, we know that current approaches include: Gradually reducing the dose Extending injection intervals (e.g