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Tirzepatide (Zepbound for weight loss, Mounjaro for diabetes), liraglutide (Saxenda), and older agents such as phentermine-topiramate (Qsymia) are also possibilities

Given their high plasticity and stem-cell-like characteristics, reactive astrocytes have been investigated as potential therapeutic targets for in neurological disorders such as ischemic stroke

It also has some effects on the brain

Clinicians initiate lofexidine at 0.53 mg three times daily and increase the dose to 2.88 mg daily as needed (92)

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