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Four -ketoacid dehydrogenase complexes ( Figure 4 ), including: (i) the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for energy production via the citric acid cycle
Through these reactions as well as its interactions with a number of proteins, glutathione is one of the major regulators of cancer cell development, progression, response to therapy and its environment leading to a number of avenues for therapeutic targeting (Figure 1)
PMID: 40813933 SSRN2025 Jan 14
Patients in the HGSH group exhibited significantly higher recurrence rates, and mortality compared to the LGSH group
Therefore, it is necessary to develop a better toolkit and standardize methods of isolation and analysis of specific subset of exosomes from in vivo tumor tissue
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