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Groups that started at 2mg and escalated gradually reported fewer and milder GI side effects than groups that started at 4mg, even when both reached the same final dose
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Whereas acute insulin treatment may benefit ApoE 4 non-carriers with normal insulin levels, chronic treatment may, in fact, induce insulin resistance [151] perhaps explaining a decline in memory function in response to insulin detemir [162]
40 Insulin also promotes protein synthesis in skeletal muscle, liver, adipose tissue and other tissues, whilst simultaneously decreasing the rate of protein degradation in these tissues
