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Nature Reviews Endocrinology, 9 (6), 357-365

Semaglutide activates GLP-1 receptors in your brain and digestive system that regulate satiety and appetite, independent of current food intake

Research published in obesity and endocrinology journals shows average weight loss of 10-15% body weight over 12 months with semaglutide therapy, regardless of formulation source

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The FDA conducted a parallel evaluation and reached a similar conclusion, stating that a causal relationship had not been established

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