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Based on these findings, we designed two FAP-targeted CAR sequences with a CD28 TMD (FAPCAR 2.1) and with an optimized TMD (FAPCAR 2.2)

Side effects may increase when peptides are used improperly or without medical supervision

Fibroblast-like synoviocytes (FLSs) contribute to pannus formation and matrix degradation through MMP-1 and MMP-3, with expression levels 5 - 10 times higher in RA synovium (Figure 1) (14)

FDA explicitly notes that compounded drugs are not FDA-approved and should be used when a patients needs cannot be met by an available approved product or when an approved product is not commercially available

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