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One study by Tufts University found that nearly 40% of American adults have a B12 deficiency, and some doctors believe the rate to be higher

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The study proved that combination therapy (60 mg duloxetine + 300 mg pregabalin) was not significantly more effective than high-dose monotherapy (either 120 mg duloxetine or 600 mg pregabalin) in reducing pain after 8 weeks of intensified treatment