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PLoS ONE 8:e55375 Collier TJ, Kanaan NM, Kordower JH (2017) Aging and Parkinsons disease: different sides of the same coin

Modulation of AMPA receptor unitary conductance by synaptic activity

Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)

Wang, B

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