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Microglia, the primary immune responders in the brain, release proinflammatory cytokines when activated, which then stimulate nearby reactive astrocytes, amplifying local neuroinflammation

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Current Medicinal Chemistry , 19 (1), 126132

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Elecoglipron is an oral small molecule GLP-1 RA (receptor agonist), Vanita Aroda, MD, director of Diabetes Clinical Research at Brigham and Womens Hospital, associate professor of medicine at Harvard Medical School, and lead author of this study, told Medical News Today

adaptive resistance acts as a transitional buffer against acute drug toxicity, buying the evolutionary window necessary for the accumulation and clonal expansion of mutations conferring acquired resistance