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However, patients who lose significant weightwhether through medication, surgery, or lifestyle changesoften maintain a slightly lower metabolic rate than predicted for their new body weight

Infographic Overview The 2025 Breakthrough Prize celebrates the complementary roles of the five recipients: Joel Habener : Habeners early work identified GLP-1 within the glucagon gene

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Sources: STEP 1 Trial, Wegovy prescribing information, Novo Nordisk

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This reduces the risk of complications and supports safer long-term use, particularly for individuals planning to remain on treatment for an extended period