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We previously reported that La 3+ and Ruthenium Red, non-selective TRP channel blockers, strongly inhibited triagonist-enhanced GSIS and significantly suppressed triagonist-induced Ca 2+ influx in 1.1B4 cells [9]

DAgostino, I., Tacconelli, S., Bruno, A., Contursi, A., Mucci, L., Hu, X., Xie, Y., Chakraborty, R., Jain, K., Sacco, A., Zucchelli, M., Landolfi, R., Dovizio, M., Falcone, L., Ballerini, P., Hwa, J., & Patrignani, P

ISBN 978-3-030-23153-8

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Anecdotally, this felt like a trend

In other words, the mean changes in these tests were toward the improvement in L-carnitine group compared to placebo