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Zinc and selenium activate the bodys own antioxidant enzymes, which, together with glutathione, intercept oxidative stress

A commonly extrapolated human-equivalent dose is roughly 2 to 10 micrograms per kilogram, though no human dose-ranging trial has been completed or published

Nitric oxide helps the blood vessels maintain their flexibility so that the blood flow is unrestricted

By integrating advances in neuroscience, pharmacology, and molecular medicine, this review emphasizes the promise of Nrf2 as a unifying therapeutic target across diverse CNS pathologies

doi:10.1016/j.addr.2018.07.009 6