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This upregulation extends to key antioxidant systems, including glutathione (GSH) and thioredoxin (TRX), which help maintain redox balance and support tumor survival [35]

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Crucially, some studies provided direct barrier or permeability-related readouts: WTD reported enhanced barrier function accompanying TNF-/IL-6 reduction ( 5.3.3 Summary box Conclusion: Intestinal barrier - systemic inflammation axis is common in a variety of interventions and models, so it is the most suitable convergence endpoint/mechanism landing point for different metabolic modules to achieve remote immune regulation