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GLP-1 was shown to manage blood sugar levels by improving insulin function, lowering glucagon levels, and delaying gastric emptying

[14] Leading medical organizations advise against them

In recent years, the FDA has begun approving GLP-1s specifically for chronic weight management to help treat obesity, as they can increase satiety, decrease hunger and result in significant weight loss

Consequently, MR-Egger may yield wider CIs, particularly in smaller cohorts