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Why that matters: cortisol and GLP-1 effectiveness are inversely linked, and perimenopausal estrogen decline dysregulates the HPA axis, raising baseline cortisol and driving hormonal belly fat redistribution that keeps women stuck at a normal BMI with real metabolic dysfunction

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Glutathione (GSH) levels in lung homogenates were determined enzymatically, and NO detection was performed using Griess reagent [1]