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ACHIEVE-3 (NCT06045221) The head-to-head comparison of orforglipron versus oral semaglutide 14 mg in patients with type 2 diabetes

Subsequently, they received intravenous injections of PBS, Ru(II)-OH, NP2, or NP4 (at a dosage of 2 mg/kg Ru) on days 0, 3, 6, and 9, respectively

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Body-weight changes, the frequency of severe food-preoccupation episodes, and temporal correlations between biomarker emergence and symptom recurrence were also evaluated to explore associations, rather than causal effects, between tirzepatide exposure and NAc oscillatory activity