Life 10:271
Nature 485 , 661665 (2012)
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However, covalent modification of the 20S proteasome by MG reduces its degradation activity, leading to persistent activation of the unfolded protein response (UPR), which ultimately triggers apoptosis and inflammatory responses (129, 130)
doi: 10.3390/jcm7060156 202 MarshBZhouYKapidzicMFisherSBlellochR
184 In a mouse model of male infertility, shilajit improved testicular function, increased sperm and testosterone production, reversed the toxic effect of the heavy metal cadmium on sperm motility and concentration, and induced fertility